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Sunday, July 26, 2020 | History

3 edition of The kinetics of lymphokine production and release by a cloned T emplifier cell found in the catalog.

The kinetics of lymphokine production and release by a cloned T emplifier cell

The kinetics of lymphokine production and release by a cloned T emplifier cell

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  • 33 Currently reading

Published .
Written in English


Edition Notes

Statementby John Mark Ely.
Classifications
LC ClassificationsMicrofilm 82/217 (Q)
The Physical Object
FormatMicroform
Paginationvii, 122 leaves
Number of Pages122
ID Numbers
Open LibraryOL3066577M
LC Control Number82163703

INTRODUCTION. T‐cell receptor (TCR) engagement by specific ligand [appropriate peptide antigen bound to human leucocyte antigen (HLA) class II molecules] induces human CD4 + T cells to begin functional programmes, including proliferation, lymphokine synthesis and secretion, phenotypic modulation of surface markers, tolerance and apoptosis. The microenvironment, e.g. antigen dose, Cited by: In in vitro production and cloning of the P cell, a bone marrow-derived null cell that expresses H-2 and Ia-antigens, has mast cell-like granules, and is regulated by a factor released by activated T by:

Studies on the humoral regulation of granulocytopoiesis have, for several reasons, met with frustration since the beginning of experimentation on this problem. Stimulators for the initiation of Cited by: 4. Alloreactive cloned T cell lines. V. Differential kinetics of IL 2, CSF, and BCSF release by a cloned T amplifier cell and its variant. J Immunol. Dec; (6)– Baker PE, Gillis S, Ferm MM, Smith KA. The effect of T cell growth factor on the generation of cytolytic T cells. J Immunol. Dec; (6)–

Ensembl ENSG ENSMUSG UniProt P P RefSeq (mRNA) NM_ NM_ RefSeq (protein) NP_ NP_ Location (UCSC) Chr 1: – Mb Chr 1: – Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the C chemokine family that is Aliases: XCL1, ATAC, LPTN, LTN, SCM-1, SCM-1a, .   Immunoregulatory role in gamma interferon production by a T cell growth factor-dependent experimental malignant glioma-specific cytotoxic T lymphocyte clone Toshiki Yamasaki M.D. 1, Hajime Handa M.D. 1, Junkoh Yamashita M.D. 1, Yoshihiko Watanabe 1, Masaaki Taguchi 1, Shigeki Kuwata 1, Yuziro Namba M.D. 1 and Masao Cited by: 6.


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The kinetics of lymphokine production and release by a cloned T emplifier cell Download PDF EPUB FB2

Alloreactive cloned T cell lines. Differential kinetics of IL 2, CSF, and BCSF release by a cloned T amplifier cell and its variant. J Immunol. Dec; (6)– Farrar JJ, Fuller-Farrar J, Simon PL, Hilfiker ML, Stadler BM, Farrar WL. Thymoma production of T cell growth factor (Interleukin 2).

J Immunol. Dec; (6) Cited by: The time course of CSF and BCSF production by L2V after stimulation with alloantigen was similar to that found with L2, although IL 2 activity was not detected at any time.

Since the release of lymphokines from both L2 and L2V cells could be induced by Con A in the absence of stimulating alloantigen, it is likely that the biologically active factors were produced by the cloned T by: Lymphokine production by human T cells in disease states.

Romagnani S(1). Author information: (1)Division of Clinical Immunology and Allergy, University of Florence, Italy. A large body of evidence suggests the existence of polarized human T cellresponses, reminiscent of Th1 and Th2 subsets described for mouse T by: Aging and lymphokine production by t cell subsets.

David N. Ernst. Corresponding Author. Department of Immunology, The Scripps Research Institute, La Jolla, California, USA.

Department of Immunology, IMM‐9, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CAby: Early in the infection, IL is produced and induces production from NK and T cells of IFN-gamma, which contributes to phagocytic cell activation and inflammation; 2.

IL and ILinduced IFN. Abstract. T cell clones are useful models for studying lymphocyte function both at the level of the individual cell and in interacting systems. Murine cytolytic and non-cytolyic T cell clones have been obtained with relative ease, and the particular procedure used to derive and maintain T cell clones may influence profoundly the characteristics of the resulting by: 5.

A clone-specific monoclonal antibody that inhibits cytolysis of a cytolytic T cell clone Article (PDF Available) in Journal of Experimental Medicine (3) April with 16 Reads. This chapter discusses the uses of cloned normal T lymphocytes.

T-cell clones offer unique advantages for a variety of immunological studies. The availability of large numbers of defined, homogeneous cell T cells will greatly facilitate efforts to identify the T-cell receptor for antigen and to define unambiguously the molecular basis for regulating and effector functions of T : Frank W.

Fitch. Differential kinetics of IL-2, CSF, and BCSF release by a cloned T amplifier cell and its variant.J, (). Biologic properties of chromatographically separated murine thymoma-derived interleukin 2 and colony-stimulating factor. Abstract. We have investigated alloantigen differences which stimulate lymphokine release and 3 H-TdR uptake in primary ‘one-way’ MLC among allogeneic mice.

When mice differing at the wholeH-2 region were tested, MIF and immune IF release was observed, along with a marked 3 H-TdR uptake. Differences atK, D, orI-S-G regions stimulate both lymphokine release and 3 H-TdR uptake, though Cited by: Andrew L.

Glasebrook. Eli Lilly Alloreactive cloned T cell lines. Differential kinetics of IL 2, CSF, BCSF release by a cloned T amplifier cell and its variant. III. Characteristics of Cloned Mis-Reactive T Cell Lines IV. Conclusions References 28 Lymphokine Production by Cytolytic and Noncytolytic Alloreactive T Cell Clones I.

Analysis of Lymphokine Production by a Noncytolytic T Cell Clone and Its Variant upon Alloantigenic Stimulation Edition: 1. Results Lymphokine production To examine the role of representative lymphokines in the defective B/6-lpr/lpr antibody response to exogenous antigen, we tested FGG-reactive B/6-lpr/lpr and Bl/6-+/+ cloned T-cell supernatants for T-cell replacing factor (TRF) activity in both normal (BALB/c) and B/6-lpr/lpr B-cell responses against the antigen by: 2.

Alloreactive cloned T cell lines. Differential kinetics of IL 2, CSF, and BCSF release by a cloned T amplifier cell and its variant.

J Immunol. Dec; (6)– Kelso A, Glasebrook AL, Kanagawa O, Brunner KT. Production of macrophage-activating factor by T lymphocyte clones and correlation with other lymphokine activities. Effect of ageing on the kinetics of acidphosphatase in cerebral hemisphere of female mice.

The kinetics of lymphokine production and release by a cloned T amplifier cell / Kinetics of. During immune responses, different classes of T cells arise: Th1, Th2, and Th Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell repertoire is critical for immune monitoring purposes.

Antigen-specific Th1, Th2, and Th17 cells can be detected by challenging peripheral blood Cited by: Summary. Lymphokine production by human melanoma tumor-infiltrating lymphocytes (TIL) was studied. Uncultured TIL produced interferon γ (IFNγ), but not interleukin-2 (IL-2) or IL-4, in response to anti-CD3 mAb or ILCited by: Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones November Proceedings of the National Academy of Sciences 82(20)   Differential kinetics of IL 2, CSF, and BCSF release by a cloned T amplifier cell and its variant.

Ely JM, Prystowsky MB, Eisenberg L, Quintans J, Goldwasser E, Glasebrook AL, Fitch FWAuthor: Margaret B. Goldman, Michael B.

Prystowsky, John Ely, Frank W. Fitch, John N. Goldman. IL-2 production in the copper deficient and zinc deficient MLCs were comparable to the control MLC IL-2 levels.

The early appearance of the IL-2 in the four MLCs is similar to the kinetics noted by others for allogeneicly stimulated cloned T cell lines (12). Production of IL-2 in the magnesium deficient MLCs was not by:.

lymphokine production in human disease A. Neoplasia Few systematic investigations of lymphokine production in cancer patients have been performed, although studies on the detection of lymphokine activity in the sera of certain tumor patients has been reported (see Chapter 2, this volume).Author: Ralph Snyderman, Linville Meadows, Marilyn C.

Pike.Aarden, L. A., et al.,Revised nomenclature for antigen non-specific T-cell proliferation and helper factors, J. Immunol. Google ScholarCited by: 2.Synchronized monkey cells pulse-labeled with [35 S]-methionine and chased for various lengths of time were extracted, and immunoprecipitations were performed using monoclonal antibodies directed against the retinoblastoma protein (RB) and SV40 T antigen (T).By following a discrete population of these two proteins through the cell cycle, the following information was obtained.