3 edition of Immunosuppression In Transplantation found in the catalog.
May 15, 1999
by Blackwell Publishing
Written in English
|The Physical Object|
|Number of Pages||140|
Liver Transplantation: Clinical Assessment and Management is the perfect tool for all gastroenterologists, hepatologists and transplant surgeons managing patients with liver disease awaiting and undergoing transplantation.. Led by James Neuberger, world experts in hepatology and transplantation provide a chronological, step-by-step approach to best . Chapter 2 Cellular and Humoral Responses in Organ Transplantation 33 Jie Wu and Wenhao Chen Chapter 3 Historical Remarks of Immunosuppressive Therapy in Organ Transplantation 51 Huifang Chen, Anlun Ma and Pierre Daloze Chapter 4 Animal Models in Immunosuppression 83 James McDaid, Christopher J. Scott, Adrien Kissenpfennig and Paulo N. Martins.
Drs. Busuttil and Klintmalm present Transplantation of the Liver 3rd Edition which has been thoroughly revised to offer you the latest protocols surgical approaches and techniques used in this challenging procedure. Encompassing today's expert knowledge in the field this medical reference book is an ideal single source for authoritative up-to-date guidance on every . immunosuppression During the last two decades lung transplantation (LTx) has become a life-saving intervention for patients presenting with end-stage respiratory disease. A successful lung transplant may result in complete restoration of lung function and normal quality of life in these very ill patients.
Offers state-of-the-art coverage of all areas of kidney transplantation such as preservation of kidneys; mechanisms of rejection and the induction of tolerance; techniques of laparoscopic live donor nephrectomy; and immunosuppression.; Contains up-to-date outcomes data and analysis of the evidence supporting current practice in the field.; Includes new information on . Histocompatibility in transplantation. 10 Tissue typing and HLA matching 11 Detecting HLA antibodies 12 Antibody-incompatible transplantation Organ allocation. 13 Organ allocation Immunosuppression. 14 Immunosuppression: induction vs maintenance 15 Biological agents 16 T cell-targeted immunosuppression Complications.
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The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity.
Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic Price: $ ISBN: OCLC Number: Description: xi, pages: illustrations ; 29 cm: Contents: Molecular and clinical therapeutics of cyclosporine in transplantation / Paul A.
Keown --Azathioprine / Roy Y. Calne --Steroids and transplantation / Rowan G. Walker --Tacrolimus / Goran B. Klintmalm --Mycophenolate Mofetil: experimental.
The book is intended for the transplant professional and the specialist who wants to stay abreast of the current status of immunosuppression in organ transplantation. The book is also useful for basic scientists who work in the field of transplantation : $ Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug : Elsevier Science.
The long-term graft survival in renal transplantation results is still controversial, the toxicity and adverse reactions of the immunosuppressive drugs are implicated, as well as cellular and humoral antigen-specific immune mechanisms; therefore, different strategies for adapting immunosuppression are used to reduce the complications associated with the use of these Author: Jorge Andrade-Sierra, Pedro Alejandro Vazquez-Galvan, HernestoHernandez-Reyes, Lydia A.
Mercado-Jáur. Immunosuppression is usually heavier in the peri-operative period and early post-transplant (induction) when the risk of rejection is higher due to a number of factors including preservation injury of the graft and sudden exposure of the recipient immune system to a load of foreign antigen.
Abstract Liver transplantation has come a long way from the early days of immunosuppression with irradiation, 6-mercaptopurine and corticosteroids.
With the advent of calcineurin inhibitors, significan progress has been made over last 25+ years. Immunosuppression management of pancreas transplant recipients is similar to that of recipients of other solid-organ transplants, including kidney transplants, which most pancreas recipients also receive.
Induction immunosuppression with anti-T-cell monoclonal or polyclonal-depleting or non-depleting agents may be used or reserved for rejection episodes. A systematic review of immunosuppressive regimens in lower immunological risk renal transplant recipients. Value Health ; A–4 Kobashigawa J, Ross H, Kfoury AG, Van Bakel A, Ewald G, Burton J, et al.
CMV infections are less frequent in de novo heart transplant recipients receiving immunosuppression with everolimus plus reduced CsA compared to MMF and standard CsA. Visceral transplant represents an immunologic challenge due to high intestinal graft immunogenicity.
Over the last 20 years, significant advances in immuno. Abstract. Legends of both Eastern and Western cultures include tales of organ transplantation.
Around B.C., the Hindu icon Ganesha, the god of wisdom and vanquisher of obstacles, was created by Shiva, who xenografted the head of an elephant onto the body of the child . transplant units, few of which utilize individual immunosuppressive drugs as suggested by the manufacturer.
Throughout this book we have presented an approach to immunosuppression based on our own practice and UK experience in general, including the use of products not licensed for transplantation. The contributions of Dr. Starzl to the medical literature of drug immunosuppression for transplantation span 50 years, with a peak in citation frequency throughout the s.
References Starzl TE, Marchioro TL, Porter KA, Iwasaki Y, Cerilli GJ: The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal. Immunosuppressive Regimens 1. Induction immunosuppression Intense IS during and immediately after Tx 2.
Maintenance immunosuppression Two or three drug regimen as long as the allograft functions 3. Treatment of Rejection Immunosuppression for rejection (ACR and AMR) 4. Tolerance Regimen - still a dream Selective unresponsiveness to donor antigen. Consequently, post-transplant immunosuppression aims to modify these responses to reduce the damage occurring to the transplanted organ by the recipient’s immune system.
Tissue Typing. Prior to transplantation, HLA tissue typing is performed in potential recipients prior to listing to reduce risk of rejection. At the time of transplantation, patients are typically treated with induction therapy, either a T-lymphocyte–depleting agent (antithymocyte globulin [Thymoglobulin]) or an interleukin 2 (IL-2) inhibitor (basilixumab).
Maintenance immunosuppression is initiated in the hospital and continued for the life of the allograft. Lung transplantation is a treatment option for selected patients who are not responding to maximal medical therapy, or for whom no effective medical therapy exists.
This book provides a comprehensive guide to the recent advances in lung transplantation, and includes coverage of donor selection, immunosuppression, infectious and noninfectious complications, and. Immunosuppression in lung transplantation remains a difficult issue, with chronic rejection continuing to plague patient outcome.
Future multicenter trials assessing current immunosuppressive therapies as well as more novel therapeutic approaches are needed to overcome potential center and regional variation in a genuinely heterogeneous patient. The only textbook devoted to the field of pediatric transplantation A definitive reference for all those interested in improving the care.
Renal transplantation is the best treatment for patients with end-stage renal disease. Over the last decades, the introduction of new immunosuppressive agents resulted into the reduction of the incidence of acute rejection and early graft loss.
Despite this progress, there has been little improvement in the average life of the transplant.Insufficient immunosuppression results in graft loss due to rejection, while excess immunosuppression results in increased morbidity and mortality from opportunistic infections and malignancies.
Indeed, graft rejection, infection, and malignancy are the three principal causes of mortality for the lung transplant recipient.
Features a new chapter on transplantation in the sensitized patient to assist you with transplant cases that present unique challenges. Describes the latest preclinical and clinical immunosuppressive strategies, to help you see the link between Reviews: 1.